![]() ![]() Particularly, it could estimate the proportion of patients with the incubation period exceeding 14 days, that was detected in 5-10% of patients by earlier studies, and has not yet been analyzed for the recently emerged strains. Moreover, the inclusion of individual-level data allows to estimate the group variability of the incubation period, instead of just reporting its mean values and their uncertainty. While the individual-level meta-analysis is more time consuming and requires communication with teams that conducted primary studies, it could explain the observed between-studies heterogeneity and provide insights about the incubation period in certain subgroups. The manuscript does not indicate whether it was not performed due to difficulties with original data provision or due to other reasons. These findings are important, however, the analysis could be more representative if considers several aspects.įirst, the observed between-studies heterogeneity, with I2 = 98.8% for the pooled analysis and similar I2 for separate SARS-CoV-2 strains, indicates substantial differences in the primary studies population, and suggests to include in the analysis moderator variables or to implement a meta-analysis with individual patient-level data. demonstrates a decrease in the mean COVID-19 incubation period that supports change in clinical features of viral transmission of different SARS-CoV-2 strains and faster spread. The systematic review presented by Wu et al. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment. ![]() ![]() Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography. ![]()
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